NUMB3RS is a drama about FBI agent Don Eppes (Rob Morrow), who recruits his mathematical-genius brother, Charlie (David Krumholtz) to help the Bureau solve a wide range of challenging crimes in Los Angeles. The two brothers take on the most confounding criminal cases from a very distinctive perspective.
　　
　　Inspired by actual cases, the series depicts how the confluence of police work and mathematics provides unexpected revelations and answers to the most perplexing criminal questions.
　　
　　A dedicated FBI agent, Don couldn't be more different from his younger brother, Charlie, a brilliant mathematician who, since he was little, has yearned to impress his big brother. As a seasoned investigator, Don deals in hard facts and evidence, whereas Charlie, a math professor at a California university, functions in a world of mathematical probability and equations.
　　
　　Now, despite their disparate approaches to life, Don and Charlie are able to combine their areas of expertise and solve some killer cases.